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Noradrenaline bitartrate monohydrate

Cat. No. M5822
Noradrenaline bitartrate monohydrate Structure
Synonym:

Levophed

Size Price Availability Quantity
100mg USD 48  USD60 In stock
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Biological Activity

Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 337.28
Formula C8H11NO3.C4H6O6.H2O
CAS Number 108341-18-0
Purity 98.13%
Solubility 64 mg/mL in DMSO
Storage at -20°C
References

[1] Zhu JX, et al, Exp Neurol. The role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex on allodynia following spared nerve injury.

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Keywords: Noradrenaline bitartrate monohydrate, Levophed supplier, Adrenergic Receptor, inhibitors

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