Free shipping on all orders over $ 500

Nolatrexed HCl

Cat. No. M9179
Nolatrexed HCl Structure
Synonym:

AG-337; NOL

Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 210 In stock
25mg USD 420 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nolatrexed HCl, also known as AG337, is a thymidylate synthase inhibitor. Nolatrexed is a non-classical TS inhibitor in that it lacks a terminal glutamate side chain and is uncharged at physiological pH. Nolatrexed does not require a specific transport mechanism to enter into cells and, once within the cell, is not a substrate for the enzyme folyl polyglutamate synthetase.

In vivo, when nolatrexed was administered to nude mice bearing Bu25TK- tumor xenografts, a time-dependent increase in antitumor activity was observed.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 357.26
Formula C14H14Cl2N4OS
CAS Number 152946-68-4
Purity >98%
Solubility DMSO: ≥ 16 mg/mL
Storage at -20°C
Related Products
S107

S107 is a Type 1 ryanodine receptor (RyR1) stabilizer.

TMB

3,3’,5,5’-Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).

Coelenterazine

Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.

Fluorescein

Fluorescein is a synthetic organic compound and dye.

SBI-0640756

SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nolatrexed HCl, AG-337; NOL supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.