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Nolatrexed HCl

Cat. No. M9179
Nolatrexed HCl Structure

AG-337; NOL

Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 210 In stock
25mg USD 420 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nolatrexed HCl, also known as AG337, is a thymidylate synthase inhibitor. Nolatrexed is a non-classical TS inhibitor in that it lacks a terminal glutamate side chain and is uncharged at physiological pH. Nolatrexed does not require a specific transport mechanism to enter into cells and, once within the cell, is not a substrate for the enzyme folyl polyglutamate synthetase.

In vivo, when nolatrexed was administered to nude mice bearing Bu25TK- tumor xenografts, a time-dependent increase in antitumor activity was observed.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 357.26
Formula C14H14Cl2N4OS
CAS Number 152946-68-4
Purity >98%
Solubility DMSO: ≥ 16 mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog 2017

Keywords: Nolatrexed HCl, AG-337; NOL supplier, inhibitors

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