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Cat. No. M2561
NMS-873 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 70 In stock
10mg USD 125 In stock
50mg USD 455 In stock
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Quality Control
Biological Activity

NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.

Product Citations
Customer Product Validations & Biological Datas
Source Nature (2017). Figure 6. NMS873 (Abmole Bioscience)
Method Western blot
Cell Lines NIH3T3 cells
Concentrations 5 μM
Incubation Time 3 h
Results In contrast to treatment with NMS873, CuET had no effect on p97 ATPase activity
Source Nature (2017). Figure 4. NMS873 (Abmole Bioscience)
Method Western blot
Cell Lines NIH3T3 cells
Concentrations 5 μM
Incubation Time 3 h
Results We confirmed UPR in cells treated with CuET or NMS873 by detecting increased markers of UPR induction, including the spliced form of XBP1s, ATF4 and phosphorylated (p-) eIF2α33
Source Nature (2017). Figure 2. NMS873 (Abmole Bioscience)
Method colony-formation assay
Cell Lines U2OS cell
Concentrations 10 μM
Incubation Time 16 h
Results Furthermore, consistent with cleavage of the 120-kDa species of the endoplasmic reticulum-tethered transcription factor NRF1 into an active 110-kDa form being a p97-dependent process30, appearance of the cleaved NRF1 form was inhibited by both CuET and NMS873
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 520.67
Formula C27H28N4O3S2
CAS Number 1418013-75-8
Purity 100.00%
Solubility DMSO 80 mg/mL
Storage at -20°C
Related p97 Products

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.

Abmole Inhibitor Catalog 2017

Keywords: NMS-873 supplier, p97, inhibitors

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