Free shipping on all orders over $ 500


Cat. No. M2561
NMS-873 Structure
Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 135 In stock
50mg USD 460 In stock
Bulk Inquiry?

Quality Control
Biological Activity

NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 520.67
Formula C27H28N4O3S2
CAS Number 1418013-75-8
Purity 100.00%
Solubility DMSO 90 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Nature (2017). Figure 6. NMS873 (Abmole Bioscience)
Method Western blot
Cell Lines NIH3T3 cells
Concentrations 5 μM
Incubation Time 3 h
Results In contrast to treatment with NMS873, CuET had no effect on p97 ATPase activity
Source Nature (2017). Figure 4. NMS873 (Abmole Bioscience)
Method Western blot
Cell Lines NIH3T3 cells
Concentrations 5 μM
Incubation Time 3 h
Results We confirmed UPR in cells treated with CuET or NMS873 by detecting increased markers of UPR induction, including the spliced form of XBP1s, ATF4 and phosphorylated (p-) eIF2α33
Source Nature (2017). Figure 2. NMS873 (Abmole Bioscience)
Method colony-formation assay
Cell Lines U2OS cell
Concentrations 10 μM
Incubation Time 16 h
Results Furthermore, consistent with cleavage of the 120-kDa species of the endoplasmic reticulum-tethered transcription factor NRF1 into an active 110-kDa form being a p97-dependent process30, appearance of the cleaved NRF1 form was inhibited by both CuET and NMS873
Product Citations
Related Products

Etanercept is a dimeric fusion protein consisting of two ligand-binding domains of human p75 tumor necrosis factor receptor and the human IgG1 Fc portion.


Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.


Lambrolizumabis a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.


Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.


TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP.

Abmole Inhibitor Catalog 2017

Keywords: NMS-873 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.