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Nimotuzumab

Cat. No. M1512
Nimotuzumab Structure
Synonym:

CAS# 780758-10-3

Size Price Availability Quantity
1mg USD 600  USD600 In stock
5mg USD 1700  USD1700 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nimotuzumab (Nimotuzumab) is the first humanized monoclonal antibody targeting epidermal growth factor receptor (EGFR). Nimotuzumab has cytolytic effects on target tumors through its ability to induce antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC). EGFR is overexpressed in a variety of solid tumors, such as head and neck cancer, lung cancer and colorectal cancer. EGFR overexpression is highly associated with high aggressiveness, high metastasis, and poor prognosis. Nimotuzumab can competitively bind EGFR and block downstream signal transduction pathway mediated by EGFR, thereby inhibiting tumor cell proliferation, inducing differentiation, promoting apoptosis and inhibiting tumor angiogenesis. Nimotuzumab failed to recognize mouse EGFR.

Another CAS# 780758-10-3

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 147656.97
Formula C6566H10082N1746O2056S40
CAS Number 828933-51-3
Purity >98%
Solubility
Storage -80°C for long term
References

[1] Ramakrishnan MS, et al. MAbs. Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin.

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Keywords: Nimotuzumab, CAS# 780758-10-3 supplier, EGFR/HER2, inhibitors

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