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Nimorazole

Cat. No. M3944

All AbMole products are for research use only, cannot be used for human consumption.

Nimorazole Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 65  USD65 In stock
10mg USD 60  USD60 In stock
50mg USD 90  USD90 In stock
100mg USD 130  USD130 In stock
200mg USD 185  USD185 In stock
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Quality Control & Documentation
Biological Activity

Nimorazole is the only such agent to have shown a significant effect in a randomized controlled trial in head and neck cancer.Comparison with a historical group of patients,treated with the CHART regimen alone and matched for irradiation volume and technique, showed that nimorazole did not increase the severity of acute normal tissue radiation effects.Encouraging tumor responses have been seen in the patients receiving nimorazole with every radiotherapy fraction.Nimorazole significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects.

Chemical Information
Molecular Weight 226.23
Formula C9H14N4O3
CAS Number 6506-37-2
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Henk JM, et al. Radiother Oncol. Treatment of head and neck cancer with CHART and nimorazole: phase II study.

[2] Cottrill CP, et al. Int J Radiat Oncol Biol Phys. Pilot study of nimorazole as a hypoxic-cell sensitizer with the "chart" regimen in head and neck cancer.

[3] Overgaard J, et al. Radiother Oncol. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85.

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Keywords: Nimorazole supplier, Anti-infection, inhibitors, activators

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