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Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. Nifurtimox was discovered empirically and its mechanism of action is unclear. It is believed that nifurtimox exerts its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen.
| Molecular Weight | 287.29 |
| Formula | C10H13N3O5S |
| CAS Number | 23256-30-6 |
| Form | Solid |
| Solubility (25°C) | DMSO: ≥13 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] R Thakare, et al. Update on nifurtimox for treatment of Chagas disease
[2] No authors listed. Am J Health Syst Pharm. Nifurtimox
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