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Nifedipine

Cat. No. M3424
Nifedipine Structure
Synonym:

BAY-a-1040

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 30  USD30 In stock
500mg USD 45  USD45 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Nifedipine (BAY-a-1040), a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal’s angina) and antihypertensive, although a large number of other uses have recently been found for this agent, such as Raynaud’s phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers.

Protocol (for reference only)
Cell Experiment
Cell lines TM4 cells
Preparation method Effects of extracellular calcium ion and calcium channel blocker on Sertoli cell phagocytosis. TM4 cells were cultured for two hours and then treated with or without 10 µM nifedipine for additional 20 hours. Fluorescent carboxyl microspheres were then added to wells for further two hours as usual. Culture medium of some untreated wells was replaced by one mM EGTA containing culture medium (Ca; 0.1 mM) just before addition of microspheres. Cells were then evaluated for phagocytosis by flow cytometric analysis. Calcium concentration of untreated or one mM EGTA growth medium was one mM or 0.1 mM, respectively.
Concentrations 10 µM
Incubation time 20 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 346.33
Formula C17H18N2O6
CAS Number 21829-25-4
Form Solid
Solubility (25°C) DMSO 59 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] N Tokuda, et al. J Urol. Phagocytosis by the murine testicular TM4 Sertoli cell line in culture

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  Catalog
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Keywords: Nifedipine, BAY-a-1040 supplier, Calcium Channel, inhibitors, activators


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