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Nifedipine (BAY-a-1040), a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal’s angina) and antihypertensive, although a large number of other uses have recently been found for this agent, such as Raynaud’s phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers.
Toxicol Appl Pharmacol. 2024 Sep 24.
Human trophoblast organoids for improved prediction of placental ABC transporter-mediated drug transport
Nifedipine purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | TM4 cells |
| Preparation method | Effects of extracellular calcium ion and calcium channel blocker on Sertoli cell phagocytosis. TM4 cells were cultured for two hours and then treated with or without 10 µM nifedipine for additional 20 hours. Fluorescent carboxyl microspheres were then added to wells for further two hours as usual. Culture medium of some untreated wells was replaced by one mM EGTA containing culture medium (Ca; 0.1 mM) just before addition of microspheres. Cells were then evaluated for phagocytosis by flow cytometric analysis. Calcium concentration of untreated or one mM EGTA growth medium was one mM or 0.1 mM, respectively. |
| Concentrations | 10 µM |
| Incubation time | 20 hours |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 346.33 |
| Formula | C17H18N2O6 |
| CAS Number | 21829-25-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 59 mg/mL |
| Storage | -20°C, protect from light, sealed |
[1] N Tokuda, et al. J Urol. Phagocytosis by the murine testicular TM4 Sertoli cell line in culture
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