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Nepetin

Cat. No. M16821
Nepetin Structure
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Biological Activity

Nepetin

Chemical Information
CAS Number 520-11-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shisong Jing, et al. Virulence. Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection

[2] Binxiang Chu, et al. J Cell Mol Med. Nepetin inhibits osteoclastogenesis by inhibiting RANKL-induced activation of NF-κB and MAPK signalling pathway, and autophagy

[3] Jufei Xu, et al. Int J Biol Macromol. Resistance of nepetin and its analogs on the fibril formation of human islet amyloid polypeptide

[4] Ning Ji, et al. Arch Pharm Res. Nepetin, a natural compound from Inulae flos, suppresses degranulation and eicosanoid generation through PLCγ1 and Akt signaling pathways in mast cells

[5] Xi Chen, et al. Biomed Pharmacother. Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells

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