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NAV-2729

Cat. No. M8929
NAV-2729 Structure
Size Price Availability Quantity
10mg USD 250 In stock
50mg USD 800 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

NAV-2729 is a selective ARF6 inhibitor with IC50 value of 1.0 μM. NAV-2729 reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model, confirming the functional relevance of this pathway and suggesting a therapeutic strategy for Gα-mediated diseases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 456.88
Formula C25H17ClN4O3
CAS Number 419547-11-8
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma.
Yoo JH, et al. Cancer Cell. 2016 Jun 13;29(6):889-904. PMID: 27265506.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NAV-2729 supplier, inhibitors

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