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Narsoplimab

Cat. No. M21387
Narsoplimab Structure
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Biological Activity

Narsoplimab, a fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody against MASP-2, inhibits lectin pathway activation and has anticoagulant effects.

Chemical Information
CAS Number 2108782-45-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ambreen Pandrowala, et al. Thromb J. Narsoplimab for severe transplant-associated thrombotic microangiopathy

[2] Samer K Khaled, et al. J Clin Oncol. Narsoplimab, a Mannan-Binding Lectin-Associated Serine Protease-2 Inhibitor, for the Treatment of Adult Hematopoietic Stem-Cell Transplantation-Associated Thrombotic Microangiopathy

[3] Eleni Gavriilaki, et al. Blood. Advancing therapeutic complement inhibition in hematologic diseases: PNH and beyond

[4] Richard A Lafayette, et al. Kidney Int Rep. Safety, Tolerability and Efficacy of Narsoplimab, a Novel MASP-2 Inhibitor for the Treatment of IgA Nephropathy

[5] Hlne Kaplon, et al. MAbs. Antibodies to watch in 2020

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