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Nandrolone phenylpropionate

Cat. No. M6123
Nandrolone phenylpropionate Structure
Size Price Availability Quantity
100mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Nandrolone phenylpropionate (NPP) is an anabolic-androgenic steroid. The low androgenicity and enhanced anabolic activity of NPP has shown to positively influence calcium metabolism and to increase bone mass in osteoporosis. Nandrolone phenylpropionate could promote fibroblast replication, increase the mRNA level of alpha1 (I) procollagen and enhance the density of AR on fibroblasts.

Chemical Information
Molecular Weight 406.56
Formula C27H34O3
CAS Number 62-90-8
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Groot MJ, et al. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. Illegal treatment of barrows with nandrolone ester: effect on growth, histology and residue levels in urine and hair.

[2] Mukherjee J, et al. Acta Pol Pharm. Development and validation of RP HPLC method to determine nandrolone phenylpropionate in different pharmaceutical formulations.

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