Free shipping on all orders over $ 500

Muscarine

Cat. No. M41864
Muscarine Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Muscarine ((+)-Muscarine) is a toxin that can stimulate the parasympathetic nervous system.

Chemical Information
Molecular Weight 174.26
Formula C9H20NO2+
CAS Number 300-54-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhong Jin. Nat Prod Rep. Muscarine, imidazole, oxazole and thiazole alkaloids

[2] Pawel Kosentka et al. PLoS One. Evolution of the toxins muscarine and psilocybin in a family of mushroom-forming fungi

[3] Zhong Jin. Nat Prod Rep. Muscarine, imidazole, oxazole, and thiazole alkaloids

[4] Zhong Jin. Nat Prod Rep. Muscarine, imidazole, oxazole and thiazole alkaloids

[5] Zhong Jin. Nat Prod Rep. Muscarine, imidazole, oxazole, and thiazole alkaloids

Related AChR/AChE Products
Zanapezil

Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor, it has potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM).

Tacrine

Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate agent.

THRX-160209

THRX-160209 is a potent antagonist at the M(2) muscarinic acetylcholine (ACh) receptor subtype that was designed using a multivalent strategy, simultaneously targeting the orthosteric site and a nearby site known to bind allosteric ligands.

Catestatin

Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide.

α-Conotoxin MII

α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Muscarine supplier, AChR/AChE, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.