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MS 21570 is a gPR171 antagonist (IC50 = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.
| Molecular Weight | 237.34 |
| Formula | C10H11N3S2 |
| CAS Number | 65373-29-7 |
| Solubility (25°C) | DMSO 23.73 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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