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MRS 2500 tetraammonium salt

Cat. No. M7003

All AbMole products are for research use only, cannot be used for human consumption.

MRS 2500 tetraammonium salt Structure

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Quality Control & Documentation
Biological Activity

MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y1 receptor (Ki = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATPγS. Prevents thrombus formation in vivo.

Chemical Information
Molecular Weight 629.29
Formula C13H18N5O8P2I.4NH3
CAS Number 630103-23-0
Solubility (25°C) Water 56.12 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jones, et al. J Pharmacol Exp Ther. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

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