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Monoethyl Phthalate

Cat. No. M31125
Monoethyl Phthalate Structure
Synonym:

MEP

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Monoethyl Phthalate is a metabolite of diethyl phthalate that acts as an agonist for estrogenic compounds and PPARγ at lower concentrations.

Chemical Information
Molecular Weight 194.18
Formula C10H10O4
CAS Number 2306-33-4
Form Solid
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shaojie Liu, et al. Environ Res. The independent and interactive effects of phthalates exposure and hypertension on the indicators of early renal injury in US adults: Evidence from NHANES 2001-2004

[2] Ying-Jie Zhang, et al. Environ Pollut. Phthalate metabolites: Characterization, toxicities, global distribution, and exposure assessment

[3] M K Dziobak, et al. Geohealth. Demographic Assessment of Mono(2-ethylhexyl) Phthalate (MEHP) and Monoethyl Phthalate (MEP) Concentrations in Common Bottlenose Dolphins ( Tursiops truncatus) From Sarasota Bay, FL, USA

[4] Wei Cai, et al. Int J Environ Res Public Health. Association between Phthalate Metabolites and Risk of Endometriosis: A Meta-Analysis

[5] Kim G Harley, et al. Hum Reprod. Association of phthalates, parabens and phenols found in personal care products with pubertal timing in girls and boys

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Keywords: Monoethyl Phthalate, MEP supplier, PPAR, inhibitors, activators


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