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Molindone HCl

Cat. No. M5796
Molindone HCl Structure
Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 190 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Molindone is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 312.83
Formula C16H25ClN2O2
CAS Number 15622-65-8
Purity >99%
Solubility 17.5 mg/mL in DMSO
Storage at -20°C
References

In vitro and in vivo genotoxicity assessment of the dopamine receptor antagonist molindone hydrochloride.
Krishna G, et al. Environ Mol Mutagen. 2016 May;57(4):288-98. PMID: 27040600.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Molindone HCl supplier, Dopamine Receptor, inhibitors

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