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ML-281 is a potent ans selective STK33 inhibitor with IC50 value of 14 nM. ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers. ML281 is a valuable addition to small-molecule probes of STK33.
| Molecular Weight | 389.47 |
| Formula | C22H19N3O2S |
| CAS Number | 1404437-62-2 |
| Solubility (25°C) | DMSO: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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