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ML213

Cat. No. M9700
ML213 Structure
Synonym:

CID-3111211

Size Price Availability
10mg USD 93 4-7 Days
25mg USD 207 4-7 Days
50mg USD 350 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ML213 (CID-3111211) is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener, with EC50 values of 230 and 510 nM for KV7.2 and KV7.4, respectively. ML213 increases maximal conductance of Kv7.5 channels with an EC50 of 0.7 ± 0.2 µM. ML213 (10 µM) also reduces deactivation rates of Kv7.5 currents by 5.9-fold on average. ML213 causes a vasorelaxation in different precontracted rat blood vessels. ML213 (10 μM) also hyperpolarizes mesenteric artery smooth muscle cells. ML213 causes a concentration-dependent shift in the V1/2 for KCNQ2 activation with an EC50 340 ± 70 nM and a maximal shift of 37.4 mV.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 257.37
Formula C17H23NO
CAS Number 489402-47-3
Purity >99%
Solubility DMSO ≥ 25 mg/mL (May need warming)
Storage at -20°C
References

Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673
Lyubov I Brueggemann, et al. Mol Pharmacol. 2014 Sep;86(3):330-41. PMID: 24944189.

Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370
T A Jepps, et al. Br J Pharmacol. 2014 Oct;171(19):4413-24. PMID: 24909207.

Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener
Haibo Yu, et al. ACS Chem Neurosci. 2011 Oct 19;2(10):572-577. PMID: 22125664.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ML213, CID-3111211 supplier, Potassium Channel, inhibitors

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