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Mizoribine

Cat. No. M1921
Mizoribine Structure
Synonym:

Bredinin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 70 In stock
50mg USD 210 In stock
100mg USD 325 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Mizoribine is a newly developed immunosuppressive agent that has low toxicity. Mizoribine (Bredinin) exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides. It arrests DNA synthesis in the S phase of cellular division. Mizoribine has a therapeutic role in some patients with chronic autoimmune urticaria and may be useful for treatment of cases not responsive to classical therapy. In vitro basophil histamine release assays suggested that Mizoribine might help to reduce anti-IgE autoantibody acting on the surface of basophils in chronic autoimmune urticaria. Mizoribine (MZR) reduced PAN-induced integrin-linked kinase activation (ILK) and phosphorylation of glycogen synthase kinase-3beta (GSK3beta) in vivo and in vitro. Mizoribine (MZR) directly prevents PAN-induced podocyte injury, possibly by affecting signaling cascades involving ILK and GSK3beta.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 259.22
Formula C9H13N3O6
CAS Number 50924-49-7
Purity >98%
Solubility DMSO 50 mg/mL
Water 50 mg/mL
Storage at -20°C
References

Mizoribine treatment for antihistamine-resistant chronic autoimmune urticaria.
Hashimoto T, et al. Dermatol Ther. 2012 Jul-Aug;25(4):379-81. PMID: 22950565.

The immunosuppressive drug mizoribine directly prevents podocyte injury in puromycin aminonucleoside nephrosis.
Takeuchi S, et al. Nephron Exp Nephrol. 2010;116(1):e3-10. PMID: 20502051.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mizoribine, Bredinin supplier, DNA/RNA Synthesis, inhibitors

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