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Mizolastine

Cat. No. M5792
Mizolastine Structure
Synonym:

SL 850324

Size Price Availability Quantity
100mg USD 105 In stock
200mg USD 185 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 432.49
Formula C24H25FN6O
CAS Number 108612-45-9
Purity >99%
Solubility Insoluble
Storage at -20°C
References

Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.
Molimard M, et al. Fundam Clin Pharmacol. 2004 Aug;18(4):399-411. PMID: 15312146.

Related Histamine Receptor Products
Meta-Fexofenadine

Fexofenadine is a nonsedating antihistamine drug which is indicated for treatment of seasonal allergic rhinitis.

Roxatidine Acetate HCl

Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.

Ranitidine HCl

Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.

Loratadine

Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.

Lafutidine

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mizolastine, SL 850324 supplier, Histamine Receptor, inhibitors

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