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Miridesap

Cat. No. M9213
Miridesap Structure
Synonym:

Ro-638695; GSK-2315698; CPHPC

Size Price Availability Quantity
5mg USD 50 In stock
10mg USD 95 In stock
25mg USD 215 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Miridesap depletes circulating SAP almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 340.37
Formula C16H24N2O6
CAS Number 224624-80-0
Purity >98%
Solubility DMSO: ≥ 90 mg/mL
Storage at -20°C
References

Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).
Kolstoe SE, et al. Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2232-40. PMID: 25084341.

Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.
Kolstoe SE, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23. PMID: 19372378.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Miridesap, Ro-638695; GSK-2315698; CPHPC supplier, inhibitors

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