Miridesap depletes circulating SAP almost completely but leaves some SAP in amyloid deposits for specific recognition by subsequently administered therapeutic anti-SAP antibodies
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO: ≥ 90 mg/mL|
Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).
Kolstoe SE, et al. Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2232-40. PMID: 25084341.
Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.
Kolstoe SE, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23. PMID: 19372378.
Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.
Fluorescein is a synthetic organic compound and dye.
SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator, which inhibits the invasive capacity of carcinoma cells with a Ki of 0.41 μM.
CID5721353 is a B-Cell Lymphoma 6 inhibitor with IC50 of 212 μM.
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