(±) -praeruptorin A is A diesterification product of cis-lactone (CKL), and is the main active component of Peucedani Radix composed of dried Peucedanum praeruptorumDunn. (±) -PRAeruptorin A has been widely used as one of the traditional Chinese medicines to study cough with thick sputum and dyspnea, non-natural cough and upper respiratory tract infection. (±) -praeruptorin A can be used as A Ca2+- reflux blocker in the study of hypertension.
Molecular Weight | 386.40 |
Formula | C21H22O7 |
CAS Number | 73069-25-7 |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage | 4°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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