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MF498

Cat. No. M10856
MF498  Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MF498 is a novel selective prostaglandin E4 receptor (EP4 receptor) antagonist with a strong affinity with the EP4 receptor, with a Ki of 0.7 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 603.69
Formula C32H33N3O7S
CAS Number 915191-42-3
Purity >98%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

[1] Patsy Clark, et al. J Pharmacol Exp Ther. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and os䲧璷Ỵ璸㧀璶

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Keywords: MF498 supplier, Prostaglandin Receptor, inhibitors

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