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MF-766

Cat. No. M10857
MF-766  Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MF-766 is a highly effective, selective and orally active EP4 antagonist.Ki The value is 0.23 nM. MF-766 behaves as a complete antagonist with its IC in functional detection50 1.4 nM (becomes 1.8 nM when 10% HS is present). MF-766 can be used for cancer and inflammatory disease research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 478.46
Formula C27H21F3N2O3
CAS Number 1050656-06-8
Purity >99%
Solubility N/A
Storage at -20°C
References

[1] Yun Wang, et al. Oncoimmunology. Combination of EP 4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

[2] John Colucci, et al. Bioorg Med Chem Lett. Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

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