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Methyldopa hydrate

Cat. No. M13892
Methyldopa hydrate Structure
Synonym:

L-(-)-α-Methyldopa hydrate; MK-351 hydrate

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a prodrug and is metabolized (α-Methylepinephrine) in the central nervous system.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 238.24
Formula
CAS Number 41372-08-1
Purity >99%
Solubility DMSO 33.33 mg/mL
Storage at -20°C
References

[1] Michael Durando, et al. Sulfasalazine-Induced Crystalluria Causing Severe Acute Kidney Injury

[2] You-Min Tang, et al. [Mechanism and kinetic of methyldopa removal by Fenton's reagent]

[3] M E Schuler, et al. Augmentation of chloral hydrate induced sleep by centrally acting antihypertensive agents

[4] S M Sorensen, et al. 5-HT2 receptor antagonists reverse amphetamine-induced slowing of dopaminergic neurons by interfering with stimulated dopamine synthesis

[5] T M Kenyhercz, et al. High-performance liquid chromatographic assay of isoquinoline alkaloid formation from reaction of biogenic amines and aldehydes

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Keywords: Methyldopa hydrate, L-(-)-α-Methyldopa hydrate; MK-351 hydrate supplier, Adrenergic Receptor, inhibitors

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