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Methyl salicylate

Cat. No. M17201
Methyl salicylate Structure
Synonym:

MESA

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Biological Activity

Methyl salicylate (Oil)

Chemical Information
Molecular Weight 152.15
Formula C8H8O3
CAS Number 119-36-8
Form Liquid
Solubility (25°C) Miscible with Alc, Glacial acetic acid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xavier Poitou, et al. Food Chem. Methyl salicylate, a grape and wine chemical marker and sensory contributor in wines elaborated from grapes affected or not by cryptogamic diseases

[2] Chi-Yuan Cheng, et al. J Agric Food Chem. Understanding Methyl Salicylate Hydrolysis in the Presence of Amino Acids

[3] Tiffany Chien, et al. ACS Synth Biol. Engineered Bacterial Production of Volatile Methyl Salicylate

[4] Silvia Carlin, et al. Molecules. Methyl Salicylate Glycosides in Some Italian Varietal Wines

[5] Ping Mao, et al. Mini Rev Med Chem. Naturally occurring methyl salicylate glycosides

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