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Cat. No. M6111
Meta-Fexofenadine Structure
Size Price Availability Quantity
5mg USD 320 In stock
10mg USD 550 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In this study, fexofenadine was used as a putative P-gp probe substrate to investigate the possible interaction with diosmin in rats by using in vitro, in situ and in vivo animal models. Moreover, pharmacokinetics of fexofenadine primarily depends on the P-gp activity without involvement of metabolism by cytochrome P450.

Cell Experiment
Cell lines The human epithelial cells COLO205
Preparation method Cells were pretreated with various concentrations of fexofenadine or with PBS and were stimulated with TNF-α.
Concentrations 50 μM
Incubation time 90 min
Animal Experiment
Animal models Male Wistar rats
Formulation pH 7.4 isotonic Dulbecco’s PBS (D-PBS) containing 25 mM glucose
Dosages 10 mg/ kg
Administration orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 501.66
Formula C32H39NO4
CAS Number 479035-75-1
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C

Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats.
Neerati P, et al. Pharmacol Rep. 2015 Apr;67(2):339-44. PMID: 25712660.

Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice.
Koh SJ, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):455-61. PMID: 25538104.

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Keywords: Meta-Fexofenadine supplier, Histamine Receptor, inhibitors

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