Free shipping on all orders over $ 500

Meta-Fexofenadine

Cat. No. M6111
Meta-Fexofenadine Structure
Size Price Availability Quantity
5mg USD 320 In stock
10mg USD 550 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In this study, fexofenadine was used as a putative P-gp probe substrate to investigate the possible interaction with diosmin in rats by using in vitro, in situ and in vivo animal models. Moreover, pharmacokinetics of fexofenadine primarily depends on the P-gp activity without involvement of metabolism by cytochrome P450.

Protocol
Cell Experiment
Cell lines The human epithelial cells COLO205
Preparation method Cells were pretreated with various concentrations of fexofenadine or with PBS and were stimulated with TNF-α.
Concentrations 50 μM
Incubation time 90 min
Animal Experiment
Animal models Male Wistar rats
Formulation pH 7.4 isotonic Dulbecco’s PBS (D-PBS) containing 25 mM glucose
Dosages 10 mg/ kg
Administration orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 501.66
Formula C32H39NO4
CAS Number 479035-75-1
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats.
Neerati P, et al. Pharmacol Rep. 2015 Apr;67(2):339-44. PMID: 25712660.

Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice.
Koh SJ, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):455-61. PMID: 25538104.

Related Histamine Receptor Products
Roxatidine Acetate HCl

Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.

Ranitidine HCl

Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.

Mizolastine

Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

Loratadine

Loratadine is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.

Lafutidine

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Meta-Fexofenadine supplier, Histamine Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.