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Megestrol Acetate

Cat. No. M5765
Megestrol Acetate Structure
Synonym:

BDH1298, SC10363

Size Price Availability Quantity
100mg USD 54  USD60 In stock
500mg USD 90  USD100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 384.51
Formula C24H32O4
CAS Number 595-33-5
Purity >98%
Solubility 33 mg/mL in DMSO
Storage at -20°C
References

Megestrol acetate for treatment of anorexia-cachexia syndrome.
Ruiz Garcia V, et al. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD004310. PMID: 23543530.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Megestrol Acetate, BDH1298, SC10363 supplier, Estrogen Receptor, inhibitors

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