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Medroxyprogesterone acetate

Cat. No. M5764
Medroxyprogesterone acetate Structure
Synonym:

NSC-26386

Size Price Availability Quantity
100mg USD 45  USD50 In stock
500mg USD 81  USD90 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 386.52
Formula C24H34O4
CAS Number 71-58-9
Purity >98%
Solubility Ethanol 10 mg/mL
DMSO 12 mg/mL
Storage at -20°C
References

Use of medroxyprogesterone acetate for hormone therapy in postmenopausal women: is it safe?
Stanczyk FZ, et al. J Steroid Biochem Mol Biol. 2014 Jul;142:30-8. PMID: 24291402.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Medroxyprogesterone acetate, NSC-26386 supplier, Estrogen Receptor, inhibitors

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