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Medroxyprogesterone acetate

Cat. No. M5764
Medroxyprogesterone acetate Structure
Synonym:

NSC-26386

Size Price Availability Quantity
100mg USD 50 In stock
500mg USD 90 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 386.52
Formula C24H34O4
CAS Number 71-58-9
Purity >98%
Solubility 12 mg/mL in DMSO
Storage at -20°C
References

Use of medroxyprogesterone acetate for hormone therapy in postmenopausal women: is it safe?
Stanczyk FZ, et al. J Steroid Biochem Mol Biol. 2014 Jul;142:30-8. PMID: 24291402.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Medroxyprogesterone acetate, NSC-26386 supplier, Estrogen Receptor, inhibitors

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