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MccC7

Cat. No. M40502
MccC7 Structure
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Biological Activity

MccC7 is a small molecule 7 peptide encoded by an E. coli plasmid with inhibitory activity against microorganisms such as Klebsiella pneumoniae, Salmonella spp. and Yersinia spp.

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rebecca F Roush et al. J Am Chem Soc. Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7

[2] David Smajs et al. Plasmid. Complete sequence of low-copy-number plasmid MccC7-H22 of probiotic Escherichia coli H22 and the prevalence of mcc genes among human E. coli

[3] Sophie Duquesne et al. J Mol Microbiol Biotechnol. Structural and functional diversity of microcins, gene-encoded antibacterial peptides from enterobacteria

[4] J E González-Pastor et al. J Bacteriol. Structure and organization of plasmid genes required to produce the translation inhibitor microcin C7

[5] J I Guijarro et al. J Biol Chem. Chemical structure and translation inhibition studies of the antibiotic microcin C7

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