MAY0132 is a selective inhibitor of the cAMP-binding Protein EPAC2 (Exchange Protein directly Activated by Cyclic AMP) subtype 2. MAY0132 has a submicromolar IC50 value at EPAC2, and no activity at EPAC1. MAY0132 is believed to act at an allosteric site, perhaps at the interface of both cAMP binding domains in the EPAC2 protein.
| Molecular Weight | 313.75 |
| Formula | C16H15ClF3N |
| CAS Number | 1895861-88-7 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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