Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) acts primarily by potentiation of central adrenergic synapses by blocking reuptake of norepinephrine at nerve endings. The pharmacologic action of Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is thought to be responsible for the drug’s antidepressant and anxiolytic effects. Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is indicated for the treatment of depressive illness in patients with depressive neurosis (dysthymic disorder) and manic-depressive illness, depressed type (major depressive disorder). Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is also effective for the relief of anxiety associated with depression.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 60 mg/mL|
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