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Manidipine

Cat. No. M3572
Manidipine Structure
Size Price Availability Quantity
10mg USD 90 In stock
100mg USD 450 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It is used clinically as an antihypertensive. At a holding potential of −37 mV, manidipine decreased the Ca2+ current at concentrations above 0.1 nM, and abolished it at 100 nM. The voltage-dependent effect of manidipine on the Ca2+ current may explain the weak negative inotropism of manidipine in ventricular muscles, and provide an electrophysiological basis for its vascular selectivity.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models stroke-prone spontaneously hypertensive rat
Formulation
Dosages 20 mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 610.7
Formula C35H38N4O6
CAS Number 89226-50-6
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Acta Pharmacol Sin (2007). Figure 5. Manidipine
Method Immunohistochemical staining
Cell Lines 8-OHdG
Concentrations 50 μm
Incubation Time
Results Manidipine treatment also provided moderate relief of oxidative stress-related DNA injury
Rating
Source Acta Pharmacol Sin (2007). Figure 3. Manidipine
Method insulin staining
Cell Lines β-cell
Concentrations 50 μm
Incubation Time 6 weeks
Results β-cell mass was quite low in the db/db control group, and it was rescued greatly after 6 weeks’ treatment by both candesartan 1 mg/kg and 10 mg/kg
Rating
References

Manidipine improves spermatogenesis in the stroke-prone spontaneously hypertensive rat.
Akagashi K, et al. J Androl. 1997 Mar-Apr;18(2):210-6. PMID: 9154516.

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Abmole Inhibitor Catalog 2017




Keywords: Manidipine supplier, Calcium Channel, inhibitors

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