Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Early decades of Madras Medical College: Apothecaries.
Raman R, et al. Natl Med J India. 2016 Mar-Apr;29(2):98-102. PMID: 27586218.
The Madras Institute of Neurology, Madras Medical College, Chennai.
Ramesh VG, et al. Neurol India. 2015 Nov-Dec;63(6):940-6. PMID: 26588630.
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