Free shipping on all orders over $ 500

Madrasin

Cat. No. M6306
Madrasin Structure
Synonym:

DDD00107587

Size Price Availability Quantity
10mg USD 110 In stock
25mg USD 220 In stock
50mg USD 360 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 311.34
Formula C16H17N5O2
CAS Number 374913-63-0
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Early decades of Madras Medical College: Apothecaries.
Raman R, et al. Natl Med J India. 2016 Mar-Apr;29(2):98-102. PMID: 27586218.

The Madras Institute of Neurology, Madras Medical College, Chennai.
Ramesh VG, et al. Neurol India. 2015 Nov-Dec;63(6):940-6. PMID: 26588630.

Related DNA/RNA Synthesis Products
Brivudine

Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.

5-methoxyflavone

5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.

T-705

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

Vidarabine

Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.

Uridine

Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Madrasin, DDD00107587 supplier, DNA/RNA Synthesis, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.