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LY500307

Cat. No. M2097
LY500307 Structure
Synonym:

Erteberel

Size Price Availability
10mg USD 220 Out of stock
50mg USD 680 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LY500307 potently binds both ERα and ERβ with Ki value of 2.68 nM and 0.19 nM. LY500307 displays potent inhibition toward ERβ with EC50 of 0.66 nM and shows full agonist function in estrogen receptor beta (ERbeta) in vitro assays (>90% relative efficacy).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 282.33
Formula C18H18O3
CAS Number 533884-09-2
Purity >99%
Solubility DMSO 50 mg/mL
Ethanol 50 mg/mL
Storage at -20°C
References

Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.
Norman BH, et al. J Med Chem. 2006 Oct 19;49(21):6155-7. PMID: 17034120.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LY500307, Erteberel supplier, Estrogen Receptor, inhibitors

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