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LY344864

Cat. No. M9308
LY344864 Structure
Synonym:

LY 344864

Size Price Availability Quantity
10mM*1mL In DMSO USD 93 In stock
5mg USD 85 In stock
10mg USD 127 In stock
25mg USD 277 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

LY344864 possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Oral and intravenous LY344864 administration potently inhibited dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 351.42
Formula C21H22FN3O
CAS Number 186544-26-3
Purity >98%
Solubility DMSO: ≥ 90 mg/mL
Storage at -20°C
References

Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey.
Jeong HJ, et al. Mol Pain. 2008 Nov 11;4:54. PMID: 19014464.

Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
Phebus LA, et al. Life Sci. 1997;61(21):2117-26. PMID: 9395253.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LY344864, LY 344864 supplier, 5-HT Receptor, inhibitors

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