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LY2886721

Cat. No. M1987
LY2886721 Structure
Size Price Availability Quantity
10mg USD 220 In stock
50mg USD 720 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LY2886721 is an ß-site amyloid protein cleaving enzyme (BACE) inhibitor with the potential to inhibit the synthesis of ß-amyloid. LY2886721 inhibits recombinant hBACE1 with an IC50 of 20 nM. In cellular assays, LY2886721 inhibits Abeta with an IC50 range of 10-19 nM. LY2886721 can also targetγ-secretase to nhibit the synthesis of β-amyloid. Oral administration of LY2886721 to PDAPP mice produced dose-dependent reductions in brain Abeta, C99 and sAPPbeta. LY2886721 is currently in a Phase II clinical trial in patients with Mild Cognitive Impairment.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 390.41
Formula C18H16F2N4O2S
CAS Number 1262036-50-9
Purity >99%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LY2886721 supplier, BACE, inhibitors

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