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LY2584702

Cat. No. M4830
LY2584702 Structure
Size Price Availability Quantity
5mg USD 95 In stock
10mg USD 130 In stock
50mg USD 400 In stock
100mg USD 680 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation.LY2584702 exhibited anti-tumour activity in preclinical analysis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 445.42
Formula C21H19F4N7
CAS Number 1082949-67-4
Purity >99%
Solubility DMSO
Storage at -20°C
References

A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.
Hollebecque A, et al. Eur J Cancer. 2014 Mar;50(5):876-84. PMID: 24456794.

A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours.
Tolcher A, et al. Eur J Cancer. 2014 Mar;50(5):867-75. PMID: 24440085.

Related S6 Kinase Products
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LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.

SL 0101-1

SL-0101-1 is a selective p90 RSK inhibitor for RSK2 with IC50 of 89 nM.

FMK

FMK is a potent and selective inhibitor of p90 ribosomal protein S6 kinaseRSK2 (wt) with IC50 of 15 nM, >600- and 200-fold selectivity for RSK2 than the C436V and T493M mutants.

PF-4708671

PF-4708671 is a novel cell-permeable inhibitor of S6K1 with Ki/IC50 value of 20 nM/160 nM.

BI-D1870

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LY2584702 supplier, S6 Kinase, inhibitors

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