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Cat. No. M2318
LY2228820 Structure

Ralimetinib dimesylate; LY2228820 dimesylate; LY2228820 2MsOH

Size Price Availability Quantity
10mg USD 195 In stock
50mg USD 600 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

LY2228820 is a novel and potent p38MAPK inhibitor. In vitro kinase enzyme activity showed that the IC50 for p38αMAPK and p38βMAPK of LY2228820 were 7 nM and 3 nM, respectively. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs.

Customer Product Validations & Biological Datas
Source Oncotarget (2016). Figure 3. LY2228820
Method colony assays
Cell Lines MDA-MB-231 cells
Concentrations 10 μM
Incubation Time 72 h
Results The triple combination significantly retarded shortterm proliferation of MDA-MB-231 cells compared to vehicle and single drug controls (p<0.001), as well as the two-agent combinations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 612.74
Formula C24H29FN6.2CH4O3S
CAS Number 862507-23-1
Purity >98%
Solubility DMSO 20 mg/mL
Water 100 mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog 2017

Keywords: LY2228820, Ralimetinib dimesylate; LY2228820 dimesylate; LY2228820 2MsOH supplier, p38 MAPK, inhibitors

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