Lupeol (Clerodol; Monogynol B; Fagarasterol (Fagarasterol) is an active pentacyclic triterpenoid with antioxidant, anti-tumor and anti-inflammatory activities. Lupeol is a potent androgen receptor inhibitor that can be used in cancer research, especially in prostate cancer with androgen-dependent phenotypes (ADPC) and castration-resistant phenotypes (CRPC).
| Molecular Weight | 426.72 |
| Formula | C30H50O |
| CAS Number | 545-47-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Donghai Li, et al. Lupeol Accumulation Correlates with Auxin in the Epidermis of Castor
[4] Fan-Shiu Tsai, et al. Lupeol and Its Role in Chronic Diseases
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