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Lupalbigenin

Cat. No. M16741
Lupalbigenin Structure
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Biological Activity

Lupalbigenin

Chemical Information
CAS Number 76754-24-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Isaraporn Polbuppha, et al. Phytochemistry. Macluracochinones A-E, antimicrobial flavonoids from Maclura cochinchinensis (Lour.) Corner

[2] Khaoula Hellal, et al. Food Res Int. 1 H NMR-based metabolomics and UHPLC-ESI-MS/MS for the investigation of bioactive compounds from Lupinus albus fractions

[3] Priyapan Posri, et al. Nat Prod Res. A new flavonoid from the leaves of Atalantia monophylla (L.) DC

[4] Aman Tedasen, et al. Biomed Pharmacother. 5,7,4'-Trihydroxy-6,8-diprenylisoflavone and lupalbigenin, active components of Derris scandens, induce cell death on breast cancer cell lines

[5] Apisara Ausawasamrit, et al. Anticancer Res. Lupalbigenin from Derris scandens Sensitizes Detachment-induced Cell Death in Human Lung Cancer Cells

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