Free shipping on all orders over $ 500

Lubiprostone

Cat. No. M3459
Lubiprostone Structure
Synonym:

CAS# 333963-40-9

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 95  USD95 In stock
25mg USD 220  USD220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Lubiprostone (Amitiza) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation. It is a bicyclic fatty acid (more precisely, prostaglandin E1) derivative that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).

Another CAS# 333963-40-9

Chemical Information
Molecular Weight 390.46
Formula C20H32F2O5
CAS Number 136790-76-6
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jamal MM, et al. Am J Gastroenterol. A randomized, placebo-controlled trial of lubiprostone for opioid-induced constipation in chronic noncancer pain.

[2] Cryer B, et al. Pain Med. A randomized study of lubiprostone for opioid-induced constipation in patients with chronic noncancer pain.

Related Products
SLK/STK10-IN-1

SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

PP405

PP405 is a potent localized mitochondrial pyruvate carrier (MPC) inhibitor that acts on cellular metabolic pathways to up-regulate LDH and activate stem cells to promote hair growth, and can be used in studies related to androgenetic alopecia.

GYM329

GYM329 is a monoclonal antibody that binds to and inhibits activation of the muscle growth inhibitor (myostatin) precursor protein target.

ZH8667

ZH8667 is a trace amine-associated receptor 1 (TAAR1)–Gs agonist.

Pegtibatinase

Pegtibatinase is a cystathionine beta synthase (CBS) regulator that can be used in studies related to homocystinuria.

  Catalog
Abmole Inhibitor Catalog




Keywords: Lubiprostone, CAS# 333963-40-9 supplier, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.