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Losartan potassium

Cat. No. M2258
Losartan potassium Structure
Synonym:

Cozaar

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 60 In stock
200mg USD 80 In stock
500mg USD 120 In stock
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Quality Control
Biological Activity

Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Losartan potassium inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Losartan potassium is an angiotensin II receptor antagonist drug.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 462.01
Formula C22H23ClKN6O
CAS Number 124750-99-8
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Losartan potassium, Cozaar supplier, Angiotensin Receptor, inhibitors

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