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Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Losartan potassium inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Losartan potassium is an angiotensin II receptor antagonist drug.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 462.01 |
| Formula | C22H23ClKN6O |
| CAS Number | 124750-99-8 |
| Purity | >99% |
| Solubility | DMSO 90 mg/mL |
| Storage | at -20°C |
| Related Angiotensin Receptor Products |
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A-779 is a specific antagonist of G-protein coupled receptor (Mas receptor). |
| Angiotensin-(1-7)
Angiotensin (1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7), inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM. |
| Losartan
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. |
| EMA401
EMA401 (also known as Olodanrigan and PD-126055) is a highly selective angiotensin AT2 antagonist. |
| Angiotensin II human
Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. |
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