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Linderane was isolated from Lindera Strychnifolia and is an irreversible inhibitor of Cytochrome P450 2C9 (CYP2C9). Linderane has been shown to relieve pain and cramps.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 260.29 |
| Formula | C15H16O4 |
| CAS Number | 13476-25-0 |
| Purity | >98% |
| Solubility | DMSO ≥ 60 mg/mL |
| Storage | 4°C , protect from light , dry , sealed |
[5] Hui Wang, et al. Mechanism-based inactivation of CYP2C9 by linderane
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