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Lincomycin hydrochloride

Cat. No. M3494
Lincomycin hydrochloride Structure
Synonym:

U10149A

Size Price Availability
1g USD 120  USD120 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Lincomycin hydrochloride is a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis. Lincomycin is an antibiotic used to treat a wide variety of bacterial infections. It has been structurally modified by thionyl chloride to its more commonly known 7-chloro-7-deoxy derivative, clindamycin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 443
Formula C18H34N2O6S.HCl
CAS Number 859-18-7
Purity >98%
Solubility DMSO 80 mg/mL
Storage at -20°C
References

[1] Bo Cheng, et al. Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish

[2] Petra Czarniak, et al. Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids

[3] A M GEDDES, et al. LINCOMYCIN HYDROCHLORIDE: CLINICAL AND LABORATORY STUDIES

[4] R G Harvey, et al. A comparison of lincomycin hydrochloride and clindamycin hydrochloride in the treatment of superficial pyoderma in dogs

[5] K Kaplan, et al. Lincomycin

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