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Levosimendan

Cat. No. M5738
Levosimendan Structure
Size Price Availability Quantity
100mg USD 100 In stock
500mg USD 270 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 280.28
Formula C14H12N6O
CAS Number 141505-33-1
Purity >99%
Solubility 56 mg/mL in DMSO
Storage at -20°C
References

Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats.
Levijoki J, et al. Eur J Pharmacol. 2015 Mar 5;750:132-40. PMID: 25641751.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Levosimendan supplier, Calcium Channel, inhibitors

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