Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory.
Cell Experiment | |
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Cell lines | RAW 264.7 cells |
Preparation method | RAW 264.7 cells were seeded in a 6-cm dish and pretreated with different concentrations of LH (2 μM) for 6 h, and then stimulated with RANKL (100 ng/mL) for 15 min. The cells were washed with icecold PBS and lysed in radioimmunoprecipitation assay (RIPA) buffer. |
Concentrations | 2 μM |
Incubation time | 6 h |
Animal Experiment | |
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Animal models | Male Sprague-Dawley rats |
Formulation | 0.5% sodium carboxymethyl cellulose (CMC) solution |
Dosages | 30 mg/kg |
Administration | oral |
Molecular Weight | 347.79 |
Formula | C14H21O5N3.HCl |
CAS Number | 24735-18-0 |
Solubility (25°C) | Water 4 mg/mL DMSO 24 mg/mL |
Storage | 4°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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