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Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory.
 |
Source | Bone (2015). Figure 2. Leonurine-hydrochloride |
| Method | qRT-PCR | |
| Cell Lines | RAW264.7 cells | |
| Concentrations | 2 μM | |
| Incubation Time | 24 h | |
| Results | The mRNA expression of RANK was upregulated in M-CSF treated BMMs. LH treatment significantly suppressed RANK mRNA expression in BMMs |
 |
Source | Bone (2015). Figure 1. Leonurine-hydrochloride |
| Method | osteoclastogenesis assay | |
| Cell Lines | RAW264.7 cells | |
| Concentrations | 2 μM | |
| Incubation Time | 5 d | |
| Results | LH inhibited osteoclastogenesis in both RAW 264.7 cells (Fig. 1A) and BMMs (Fig. 1B) in a dose-dependent manner from 0.5–2 μM. |
| Cell Experiment | |
|---|---|
| Cell lines | RAW 264.7 cells |
| Preparation method | RAW 264.7 cells were seeded in a 6-cm dish and pretreated with different concentrations of LH (2 μM) for 6 h, and then stimulated with RANKL (100 ng/mL) for 15 min. The cells were washed with icecold PBS and lysed in radioimmunoprecipitation assay (RIPA) buffer. |
| Concentrations | 2 μM |
| Incubation time | 6 h |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley rats |
| Formulation | 0.5% sodium carboxymethyl cellulose (CMC) solution |
| Dosages | 30 mg/kg |
| Administration | oral |
| Molecular Weight | 347.79 |
| Formula | C14H21O5N3.HCl |
| CAS Number | 24735-18-0 |
| Solubility (25°C) | Water 4 mg/mL DMSO 24 mg/mL |
| Storage | 4°C, dry, sealed |
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