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Lauryl benzalkonium chloride

Cat. No. M39557
Lauryl benzalkonium chloride Structure
Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Lauryl benzalkonium chloride is a cationic surfactant.

Chemical Information
Molecular Weight 339.99
Formula C21H38ClN
CAS Number 139-07-1
Form Melting point: ~42°C
Solubility (25°C) DMSO 90 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vanessa Cola Thomazini et al. Daru. Impact of concerning excipients on animal safety: insights for veterinary pharmacotherapy and regulatory considerations

[2] Colby L Presley et al. Dermatitis. The History of Surfactants and Review of Their Allergic and Irritant Properties

[3] Bohaty Benjamin et al. Skin Res Technol. Visual and confocal microscopic interpretation of patch tests to benzethonium chloride and benzalkonium chloride

[4] Seon-Hwa Kim et al. Tissue Eng Regen Med. Tissue Engineered Mini-Cornea Model for Eye Irritation Test

[5] Christoph Federer et al. J Pharm Sci. Preparation and Evaluation of Charge Reversal Solid Lipid Nanoparticles

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