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Lafutidine

Cat. No. M5727
Lafutidine Structure
Synonym:

FRG-8813

Size Price Availability Quantity
10mg USD 50 In stock
50mg USD 130 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 431.55
Formula C22H29N3O4S
CAS Number 118288-08-7
Purity >99%
Solubility 86 mg/mL in DMSO
Storage at -20°C
References

Efficacy of Lafutidine Versus Famotidine in Patients with Reflux Esophagitis: A Multi-Center, Randomized, Double-Blind, Non-inferiority Phase III Trial.
Kim EH, et al. Dig Dis Sci. 2015 Jun;60(6):1724-32. PMID: 25532503.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Lafutidine, FRG-8813 supplier, Histamine Receptor, inhibitors

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