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Lafutidine

Cat. No. M5727
Lafutidine Structure
Synonym:

FRG-8813

Size Price Availability Quantity
10mg USD 50  USD50 In stock
50mg USD 125  USD125 In stock
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Quality Control & Documentation
Biological Activity

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

Chemical Information
Molecular Weight 431.55
Formula C22H29N3O4S
CAS Number 118288-08-7
Solubility (25°C) 72 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kim EH, et al. Dig Dis Sci. Efficacy of Lafutidine Versus Famotidine in Patients with Reflux Esophagitis: A Multi-Center, Randomized, Double-Blind, Non-inferiority Phase III Trial.

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Keywords: Lafutidine, FRG-8813 supplier, Histamine Receptor, inhibitors, activators


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