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Labetalol hydrochloride is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors. Labetalol induces impaired cerebral autoregulation (CA) during the first day of life, with CA returning to a normal status by the third day after birth. This effect was hypothesized to be caused by labetalol-induced vasodilation. Labetalol HCl is used in the treatment of hypertensive disorders of pregnancy (HDP).
Toxicol Appl Pharmacol. 2024 Sep 24.
Human trophoblast organoids for improved prediction of placental ABC transporter-mediated drug transport
Labetalol hydrochloride purchased from AbMole
| Molecular Weight | 364.87 |
| Formula | C19H25ClN2O3 |
| CAS Number | 32780-64-6 |
| Solubility (25°C) | DMSO 90 mg/mL Water 12 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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